B3 Nicotinamide Prevents Alzheimer In Transgenic Mice - Will It Do The Same In Humans?? We Shall See

Keep your eyes on vitamin B3 news. Vitamin B3 also known as Nicotinamide (AKA Niacinamide) have been found to prevent Alzheimer’s pathology and improve memory in transgenic mice. Studies are on the way to find if the same effect is found in humans.

Nicotinamide decrease levels of phosphorylated tau which is one of the key neuropathological hallmarks of Alzheimer’s disease. Tau is involved in the formation of mircotubules which can be thought of as the train tracks (or key transportation system) along the length of the cell. Without it, both intracellular and extracellular communication can’t occur. It also increases the stability of this transportation system via other mechanisms, and works to increase p25, a protein which has been linked to improved learning and memory.

Phase 2 trials at UC Irvine have started, this phase is looking for patients who are in the early stages of alzheimer’s. Keep your eyes on phase 2 and 3 of these clinical trials

Vitamin B3 is easily found in meat, fish, beans, potatoes and cereals, comparable [to the mice] doses for humans are far higher than is found in one’s diet.

Investigators at UC Irvine are starting a phase 2 trial in humans by giving their subjects 1,500 mg twice a day. That is 3000 mg a day. Common multivitamins contain about 10mg only. The recommended daily dose is 16mg for men and 14mg for women.

Taking 1000mg a day or more could induce liver toxicity and other side effects, thus caution and more information on safety is needed.

Nicotinamide belongs to a class of compounds called HDAC inhibitors, which have been shown to protect the central nervous system in rodent models of Parkinson’s and Huntington’s diseases and amyotrophic lateral sclerosis. Clinical trials are underway to learn whether HDAC inhibitors help ALS and Huntington’s patients.

An observational prospective study conducted by Martha. C. Morris at Rush University showed that in their Chicago population of 3718 subjects that those who consumed more niacin (a precursor to nicotinamide) over a 5.5 yr period had substantially less cognitive decline. This same study showed in a smaller subset that those who consumed more niacin also had a 70% lower risk of Alzheimer’s disease.

Stay Informed

There seems to be enough promising results so far to warrant keeping a close watch on B3 research. Many people, including myself, would like to see their memory improved and would like to decrease their chances of getting Alzheimer’s.

What Is The Truth - Will It Be Known?

Due to the simplicity of this solution (i.e. over the counter vitamin that is not expensive or patentable) I hope that the research is not influenced in any way by large corporations that would rather patent a drug to make a profit.

The Best Things Are Simple (or Natural)

It is my observation and belief that MOST good and beneficial things in life are simple and found in nature. Most of the time, naturally occurring things and simplicity do miracles. This observations is true in many fields, from medicine, to wellness, to physics and math, computer science, and chemistry, etc… The best equations and solutions out there are simple, and esthetically appealing (pretty, just as is Nature).

For more information & resources check out:

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Experiment: I Will Take Vitamin B3 (AKA Nicotinamide or Niacinamide ) To Improve Memory

Based on recent findings mentioned in this article, I would like to start taking B3 (Nicotinamide, also known as niacinamide and nicotinic acid amide) and see if it improves my memory. I bought the vitamin, I believe the needed dosage is 1000mg a day, I read this could harm the liver so I’d doing more research. I also need to do 1 memory test before and 1 after. How long should I take the vitamin for?

I’m writing this here to bounce this idea off you, any suggestions you wanna share?

This is not an exact scientific study, I don’t have a clone of me that can take a placebo, etc.. I’m only hoping to get an improvement on memory.

I will post back here with more research info and an update on my little experiment.

Soups That Have MSG

I am a guy that loves soup, I have soup when I’m cold, sick, when I have a migraine, at restaurants, etc… I have been migraine free for more than a week now, and a couple days ago I ate soup. Within an hour of eating it I had a headache. Luckily, the headache did not develop into a migraine but it prompted me to check the ingredients on the soup.

I always read ingredients, but somehow I assumed that soup was healthy and I overlooked reading the ingredients. I was surprised to find MSG (Monosodium glutamate) in the ingredients of my soup. I decided to take action.
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Improve Memory With Vitamin B3!

I just received this info from a friend:

Vitamin B3 Reduces Alzheimer’s Symptoms, Lesions: Clinical Trial On Nicotinamide Effect In Alzheimer’s Patients. It also improves memory. Over the counter B3 should WORK!

ScienceDaily (Nov. 5, 2008) — An over-the-counter vitamin in high doses prevented memory loss in mice with Alzheimer’s disease, and UC Irvine scientists now are conducting a clinical trial to determine its effect in humans.

Nicotinamide, a form of vitamin B3, lowered levels of a protein called phosphorylated tau that leads to the development of tangles, one of two brain lesions associated with Alzheimer’s disease. The vitamin also strengthened scaffolding along which information travels in brain cells, helping to keep neurons alive and further preventing symptoms in mice genetically wired to develop Alzheimer’s.

“Nicotinamide has a very robust effect on neurons,” said Kim Green, UCI scientist and lead author of the study. “Nicotinamide prevents loss of cognition in mice with Alzheimer’s disease, and the beauty of it is we already are moving forward with a clinical trial.”

The study appeared online Nov. 5 in the Journal of Neuroscience.

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Fat, The Good And The Bad

Fats are essential to your body and health. Fats help your body absorb nutrients, they help your nerves function, they keep your cells’ membranes (walls) healthy, keep your skin and hair healthy, and much more. The most important organ in your body, your brain, is basically made off 50% fat.

All fats are not created equal, however. Some fats promote your health, others increase the risk of heart disease, cancers, and even cause aging and general sickness.

So what should we do? Your goal is to replace all bad fats with good fats in your diet. This article provides some guidance

The Bad Fats:

• Saturated Fats are Found In:
  Animal products such as meat, dairy, eggs and seafood. Some plants are also high in saturated fats such as coconut oil, palm oil and palm kernel oil.
  Effects:
  Raise total blood cholesterol as well as LDL cholesterol (the bad cholesterol).
• Hydrogenated Fats/Oils
  When liquid oils are “hydrogenate” trans fatty acids are formed.

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Holistic Dentistry Tooth Extraction Vs. A Conventional Root Canal

Most holistic dentists prefer to extract a tooth than to do a root canal mainly because they believe root canals are never a 100% sterile and bacteria left behind could flourish if your immune system is compromised. My (non-holistic) dentist said that 95% o root canals are successful, this leaves 5% of root canals to fail. If they fail, an infection can occur at the bone structure that may not be easily detectable.

I found that not all holistic dentists have this position, almost none of the traditional dentists prefer extraction over a root canal. Over 95% of root canals are successful. So many people have had root canals, multiple of them. These root canal procedures are done routinely and safely. However, just because every body else is doing something doesn’t mean that it’s the best choice. For instance, take drinking pop, or using cell phones, eating fast food, eating lots of meat, smoking, getting drunk, need I continue?.. Many people take actions that negatively impact their well being for whatever reasons, be it lack of information, disinformation, ignorance, lack of interest, etc…

Here, in trying to decide if root canals are good or bad, IMHO (In my humble opinion), we are faced with a lack of information, making deciding what’s best a little tricky. I shared what I know here and ask you to contribute what you know so we can all benefit.

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